链脲佐菌素致大鼠糖尿病性白内障的发病机制
2013-07-03 01:06
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作者：丁正华，严宏，郭勇，哈文静，王建伟【关键词】 糖尿病性白
作者：丁正华，严宏，郭勇，哈文静，王建伟
【关键词】 糖尿病性白内障；链脲佐菌素；发病机制
【Abstract】 AIM: To set up the diabetic cataract model and to explore the mechanism of diabetic cataract in rats induced by streptozotocin (STZ). METHODS: Diabetic rats were made by a single intaperitoneal injection of STZ (65 mg/kg). The changes of plasma glucose, urine glucose and body weight were monitored and the progression of lens opacification was recorded using the slit lamp every week. At 13th week, the levels of glutathione reductase (GR), catalase (CAT), glutathione (GSH) and glycated protein in lens were determined. RESULTS: About 70% (14/20) of the rats responded to the streptozotocin injection and the diabetic symptoms were observed in these rats. Only one rats （1/14） was rejected for the decrease of plasma glucose (
