甘草酸药理作用及机制的研究进展论文(3)
2013-08-15 01:19
导读:7 抗氧化作用 GA的抗氧化作用也是其新颖的作用领域之一,且表现出的显著效果逐渐引起科学家的重视[20,21]。类胡萝卜素中的β-GA为超分子复合体,具有
7 抗氧化作用
GA的抗氧化作用也是其新颖的作用领域之一,且表现出的显著效果逐渐引起科学家的重视[20,21]。类胡萝卜素中的β-GA为超分子复合体,具有罕见的抗氧化还原的特性。EPR的白旋捕获技术证明,络合结构的GA可增加对斑蝥黄和胡萝卜素的体内清除速率,比过氧化氢清除速率快10mmn[22]。
本文将GA丰富的理活性和作用进行了详细的介绍,以及相对深入的构效关系的研究,为以GA为先导物,合理地进行分子设计合成新化合物的研究确定了重要方向。随着研究的不断深入,GA也将被更为广泛地应用于各种相关疾病的治疗中,为人类造福。
参考文献:
[1] Chung,J G,Chang H L,Lin W C,et al.Inhibition of N-Acetyltransferase activity and DNA-2-Aminofluorene adducts by glycyrrhizic acid in human colon tumor cells[J].Food and Chemical Toxicology,2000,38(2-3):163-172.
[2] Jung G D,Yang J Y,Song E S,et al.Stimulation of melanogenesis by glycyrrhizin in B16 melanoma cells[J].Exp Mol Med,2001,33(3):131-135.
[3] 陶春祥.甘草酸的药用研究[J],中华实用中杂志,2004,17(15):2285.
[4] Hase K J,Xiong Q B,Basnet P,et al.Inhibitory effect of tetrahydroswertianolin on tumor nccrosis factor-α-dcpcndcnt hic apoptosis in micc[J].Biochemical Pharmacology,1999,57(12):1431-1437.
[5] Mauro S,Cristina F,Armanini D,et al.Glycyrrhctinic acid-induccd pcrmcability transition in rat liver mitochondria[J].Biochemical Pharmacology,2003,66(12):2375-2379.
[6] Tucker G R.Adrenocorticotropic hormone in the aetiology and regression of neuroblastoma[J].Medical Hypotheses,2002,59(2):117-128.
[7] 李翠芹.甘草有效成分甘草酸和甘草酸及其衍生物的药理作用研究进展[J].中华研究与实践,2004,2(3):48-51.
(科教作文网http://zw.ΝsΕAc.com发布) [8] Lin J C.Mcchanism of action of glycyrrhizic acid in inhibition of Epstcin-Barr virus replication in Vitro[J].Antiviral Research,2003,59(1):41-47.
[9] Chan H T,Chan C and Ho J W.Inhibition of glycyrrhizic acid on aflatoxin B1-induced cytotoxicity in hepatoma cells[J].Toxicology,2003,188(2-3):211-217.
[10] Lin G,Nnane I P and Cheng T Y.The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats[J].Toxicon,1999,37(9):1259-1270.
[11] Romcro M R,Thomas E,Scrrano M,A,et al.Effcct of artemisinin/artcsunatc as inhibitors of hepatitis B virus production in an“in vitro”replicative system[J].Antiviral Research,2005,68(2):75-83.
[12] Cheng J M,Lin H J,Hsu Y H,et al.A quantitative bioassay for HIV-1 gene expression based on UV activation:effect of glycyrrhizic acid[J].Antiviral Research,2004,62(1):27-36.
[13] 史桂兰,胡志浩.甘草.酸药酸药理作用及临床研究进展[J].天津
药学,2001,13(1):10-12.
[14] Robcrt A J,Guinn J S,Harpcr M L,et al.Liquoricc consumption and salivary testosterone concentrations.The Lancet,2001,358(9293):1613-161.
[15] Armanini D,Mattarcllo M J,Fiorc C,et al.Licoricc rcduccs scrum tcstostcronc in healthy women[J].Steroids,2004,69(11-12):763-766.
[16] Duax W L and Debashis G.Structure and function of steroid dehydrogenases involved in hypertension,fertilyty,and cacer[J].Steroids,1997,62(1):95-100.
[17] Raphael T J and Kuttan G.Effect of naturally occurring triterpenoids glycyrrhizic acid,ursolic acid,oleanoliic acid and nomilin on the immune system[J].Phytomedicine,2003,10(6-7):483-489.
[18] Statti G A,Tundis R,Sacchetti G,et al.Variability in the content of active constitucnts and biological activety of Glycyrrhiza glabra[J].in press.
[19] 仰礼真,姚望,祁小燕,等.甘草次酸对豚鼠心室肌单个细胞L型钙通道的影响[J].中国新药与床药理,2002,13(3):161-163.
内容来自www.nseac.com
[20] Polyakov N E,Leshina T V,Salakhutdinov N F,et al.Antioxidand and redox properties of supramolescular complexes of carotenoids with βglycyrrhizic acd[J].in Press.
[21] Frocmming G R and O`Bricn N M.U937 Cells As A Model To Study The Eeeect of Phytochemicals on Superoxide Anion Production[J].Nutrition Research,1977,17(7):1091-1103.
[22] Nwe K H H,Hamid A,Morat P B,et al.Differential regulation of the oxidative 11β-hydroxystcroid dchydrogcnasc activety in tcstis and liver[J].Steroids,2000,65(1):40-45.