P糖蛋白在乳腺癌原发性耐药过程中的表达
2015-04-23 01:00
导读：药学论文毕业论文，P糖蛋白在乳腺癌原发性耐药过程中的表达样式参考，免费教你怎么写，格式要求，科教论文网提供大量范文样本：作者：赵菲，姜军，范林军，杨新华，张毅【关键词】 基因 Pglycoprotein
作者：赵菲，姜军，范林军，杨新华，张毅
【关键词】 基因
Pglycoprotein expression in the development of primary multidrug resistance in breast carcinoma
【Abstract】 AIM: To study the expression and significance of Pglycoprotein (Pgp) in the development of multidrug resistance in breast cancer. METHODS: The expression of Pgp and MDR1 mRNA were detected by immunohistochemistry and reverse transcriptionpolymerase chain reaction (RTPCR) in the specimens from 25 breast cancer patients with neoadjuvant chemotherapy (NAC group), 15 breast cancer patients without neoadjuvant chemotherapy (nonNAC group) and 10 patients with breast adenosis (control group). RESULTS: The positive rate of Pgp expression was 84.0%（21/25）, 46.7%（7/15）and 0 in NAC group, nonNAC group and control group, respectively. MDR1 mRNA expression was 84.0%（21/25）, 53.3%（8/15）and 10%（1/10） in three groups respectively. Significant difference was found between the three groups (P
