液体复苏加1,6-FDP对严重烧伤患者心脏功能保护
2014-03-13 01:09
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作者:黄金华,刘亦峰,左四琴,郑绪强,夏仲芳,林华,徐刚,周杰
作者:黄金华,刘亦峰,左四琴,郑绪强,夏仲芳,林华,徐刚,周杰
【摘要】目的观察液体复苏加1,6-FDP对严重烧伤患者心脏功能的影响。方法采用随机双盲对照法,将30例严重烧伤患者随机分为1,6-FDP治疗组(A组,n=15)和对照组(B组,n=15),两组患者均按国内常用烧伤补液公式计算补液量复苏,A组患者静滴1,6-FDP10g/次,每日2次。两组患者于入院后均置入Swan-Ganz漂浮导管,连接血流动
力学监测仪,于入院时及伤后8、16、24、36、48h监测患者的心排量(CO)、心排指数(SI),每搏量(SV),每搏指数(SI)。结果两组患者入院时心功能有关指标均显著下降,伤后8h后A组各时相点心功能指标均显著高于B组。结论在液体复苏的同时,应用1,6-FDP对严重烧伤患者的心脏功能具有很好的保护作用。
【关键词】严重烧伤;心脏功能;1,6-二磷酸果糖
Theprotectiveeffectoffluidresuscitationplus1,6-FDPonheartfunctiomwithseverelyburnedpatients
HUANGJin-hua,LIUYi-feng,ZUOSi-qin,etal.DepartmentofBurnandPlasticSurgery,TheAffiliatedHospitalofYangzhouUniversityMedicalCollege,Yangzhou225001,China.
【Abstract】ObjectiveToinvestigatetheprotectiveeffectoffluidresuscitationplus1,6-FDPoncardiacfunctionwithseverelyburnedpatients.Methods30patientsofseverelyburnedweredividedintotwogroups.Thepatientsofgroupone(Agroup,n=15)weretreatedwithresuscitationplus1,6-FDP.ThepatientsofgroupB,n=5receivedfluidrecuscitationonly.Swan-GanzcatheterwereinsertedtomonitorhemodynamicsincludingCO,CI,SVandSIafteradmissionat8,16,24,36and48hoursprostburn.ResultsThelevelsofcardiacfunctionofthetwogroupspatientswassignificantlydropedafteradmission.ThelevelsofcardiacfunctioninAgrouppatientswereevidentlyhigherthanthoseinBgroup(P<0.01,P<0.05)alltimepointsat8hourspostburn.ConclusionOurdatademonstratethattheadministrationof1,6-FDPplusfluidresuscitationmaybeoftheimportantprotectionroleforcardiacfunctionofseverelyburnedpatients.
大学排名 【Keywords】severelyburn;cardiacfunction;1,6-FDP(fructosediphosptate)
严重烧伤