H4受体介导组胺刺激AtT论文
2013-07-04 01:07
导读：药学论文毕业论文，H4受体介导组胺刺激AtT论文论文样本，在线游览或下载，科教论文网海量论文供你参考：
作者：孟嘉，谢建军，杨铁虹，王海芳，李明凯，胡静,罗晓星 【关
作者：孟嘉，谢建军，杨铁虹，王海芳，李明凯，胡静,罗晓星
【关键词】 组胺
【Abstract】 AIM: To clarify the subtype of histamine (HA) receptor which mediates Adrenocorticotropic Hormone(ACTH) release from mouse anterior pituitary tumor cell line AtT20. METHODS: ELISA assay was used to determine the effects of a variety of histamine receptor subtypespecific agonists and antagonists on ACTH release from AtT20 cells. The expression of H4 receptor mRNA on AtT20 cells was detected by RTPCR and the PCR product was sequenced. RESULTS: ① HA (108 mol/L) significantly accelerated the release of ACTH (pmol/L) from AtT20 cells （5.7±1.1 vs 2.7±0.6 in control, P
