多囊卵巢综合症患者的胰岛素抵抗(5)
2014-10-03 01:25
导读：-a刺激后的反应浓度均下降；④卵巢17α羟孕酮基础浓度及GnRH-a刺激后反应浓度 也下降；⑤约40%～50%患者恢复月经规则来潮，少数自发排卵并受孕；⑥对糖
-a刺激后的反应浓度均下降；④卵巢17α羟孕酮基础浓度及GnRH-a刺激后反应浓度
也下降；⑤约40%～50%患者恢复月经规则来潮，少数自发排卵并受孕；⑥对糖耐量
低减及血脂异常也有逆转作用。其中，二甲双呱每日剂量为1 500～1 700 mg，2～
6个月；曲格列酮每日剂量200～400 mg，3个月。
4.其他降糖药。阿卡波糖(acar- bose)为α-葡萄糖苷酶抑制剂， 通过抑制小
肠内单链淀粉分解为葡萄糖，有效延缓葡萄糖在小肠内的吸收。PCOS患者可试用，
每日150～300mg［17］。磺脲类降糖药因刺激胰岛素分泌、加重高胰岛素血症，为
PCOS患者禁用［11］。2型糖尿病、高脂血症及高血压病是IR的代谢并发症，这些
疾病的治疗不同于相应原发病的治疗，在于避免使用诱导或加重IR及糖耐量低减的
药物，如β受体阻滞剂、大剂量利尿剂及烟酸类调脂药［11］。IR一旦发展为糖尿
病并发症，其处理与单纯2型糖尿病相同。
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